Preface a Look at the Future of Macromolecular Structure Determination

نویسندگان

  • DUILIO CASCIO
  • KENNETH GOODWILL
  • EDWARD MARCOTTE
چکیده

itself? Here, we'll gaze into our crystal ball at the future of just one discipline, macromolecular crystallography, and make some guesses as to how the discipline will evolve during our lifetimes. In the past few decades, macromolecular crystallographers have improved and streamlined all of the steps of solving structures-from cloning, purification, and crystallization, to phasing and refinement. But even today, a well-established lab with experienced molecular biologists and crystallographers will often take six months to a year to do all these steps. Why can't structures be solved more quickly, as in the case of small molecule crystallography? What are the bottlenecks, and which techniques need to be improved?

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تاریخ انتشار 1998